CVE-2026-31971: HTSlib is a library for reading and writing bioinformatics file formats.

HTSlib is a library for reading and writing bioinformatics file formats.

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. When reading data encoded using the `BYTE_ARRAY_LEN` method, the `cram_byte_array_len_decode()` failed to validate that the amount of data being unpacked matched the size of the output buffer where it was to be stored. Depending on the data series being read, this could result either in a heap or a stack overflow with attacker-controlled bytes. Depending on the data stream this could result either in a heap buffer overflow or a stack overflow. If a user opens a file crafted to exploit this issue it could lead to the program crashing, overwriting of data structures on the heap or stack in ways not expected by the program, or changing the control flow of the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Description from the National Vulnerability Database, published by GitHub

What it means for a small business

If your business uses htslib, install the vendor's update. If you're not sure whether you use it, ask whoever manages your computers.

How likely is an attack? The Exploit Prediction Scoring System, run by FIRST (the global association of security response teams), puts the odds of this one being exploited in the next 30 days at 0.35%, higher than 28% of CVEs. That’s low, but low isn’t zero, and the odds jump the day someone publishes an exploit. Scored October 28, 2026, updated daily.

Check your own setup

Website check: reads what your site runs from the outside (WordPress version, plugins it can see, old server software) and matches it against this database.
Server check: what your web server says about itself, and whether that version has known flaws.

Sources

Part of the Huttenlocher Technologies vulnerability database, refreshed twice a day from CISA and the NVD. The title, category and plain-language guidance are ours; check the linked record before acting on a detail. This is general guidance, not a review of your systems.

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