CVE-2026-31966: HTSlib is a library for reading and writing bioinformatics file formats.

HTSlib is a library for reading and writing bioinformatics file formats.

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. As one method of removing redundant data, CRAM uses reference-based compression so that instead of storing the full sequence for each alignment record it stores a location in an external reference sequence along with a list of differences to the reference at that location as a sequence of "features". When decoding CRAM records, the reference data is stored in a char array, and parts matching the alignment record sequence are copied over as necessary. Due to insufficient validation of the feature data series, it was possible to make the `cram_decode_seq()` function copy data from either before the start, or after the end of the stored reference either into the buffer used to store the output sequence for the cram record, or into the buffer used to build the SAM `MD` tag. This allowed arbitrary data to be leaked to the calling function. This bug may allow information about program state to be leaked. It may also cause a program crash through an attempt to access invalid memory. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue.

Description from the National Vulnerability Database, published by GitHub

What it means for a small business

If your business uses htslib, install the vendor's update. If you're not sure whether you use it, ask whoever manages your computers.

How likely is an attack? The Exploit Prediction Scoring System, run by FIRST (the global association of security response teams), puts the odds of this one being exploited in the next 30 days at 0.54%, higher than 45% of CVEs. That’s low, but low isn’t zero, and the odds jump the day someone publishes an exploit. Scored October 28, 2026, updated daily.

Check your own setup

Website check: reads what your site runs from the outside (WordPress version, plugins it can see, old server software) and matches it against this database.
Server check: what your web server says about itself, and whether that version has known flaws.

Sources

Part of the Huttenlocher Technologies vulnerability database, refreshed twice a day from CISA and the NVD. The title, category and plain-language guidance are ours; check the linked record before acting on a detail. This is general guidance, not a review of your systems.

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